Methamphetamine and the genomics of intestinal DEGs obtained from the methamphetamine-induced mouse IBD model and bioinformatic analysis showed that methamphetamine can cause a specific type of IBD. These results provide new insights into the relationship between methamphetamine abuse and IBD. Methamphetamine is one of the most commonly abused drugs, so all doctors should be aware of its various effects on different organs in the body. Regarding its gastrointestinal sequelae, there are few reports of ischemic colitis induced by its vasoconstrictive effects.
This is the first report of an isolated small intestine infarct that has led to death due to methamphetamine toxicity. A 40-year-old woman with a history of medical treatment for obesity was referred to the hospital with severe chest and back pain, sweating, nausea, agitation, high blood pressure, bradycardia and, later, lethargy and vasomotor instability. The cardiac evaluations were normal and a toxicological urine analysis revealed methamphetamine. Subsequently, abdominal pain predominated and ultrasound revealed signs of intestinal infarction.
He did not agree to surgery and then succumbed. The autopsy found gangrene and perforation of the distal ileum. The cause of death was determined to be intestinal gangrene following methamphetamine toxicity. Methamphetamine has anorexic effects and is therefore used in some diet pills; users may not even know that they are using methamphetamine.
Therefore, in cases of known abuse of Alzheimer's disease or of people using unknown weight-reducing medications who have gastrointestinal complaints or abdominal pain, intestinal ischemia should be considered and, if possible, intervened promptly. Methamphetamine use is a rare cause of intestinal ischemia, but it is clinically important due to its high morbidity and mortality. Knowledge of methamphetamine-induced intestinal ischemia has been limited to a few case reports. In general, methamphetamine is considered a neurotoxic drug and previous methamphetamine studies have focused primarily on the cerebral nervous system (CNS).
We also evaluated proinflammatory factors (IL-6, INF-gamma, TNF-α and NF-1b) and observed that intestinal tissues were stained with hematoxylin and eosin (HE) in the animal model with methamphetamine to explore inflammatory bowel injury caused by methamphetamine.
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